Beyond MHC. Polymorphism and expression levels of non-MHC immune genes and their associations with parasitic infections in natural population of wild rodents.
2013-2016, National Science Centre, Grant no. 2012/07/B/NZ8/00058
Genes of the major histocompatibility complex (MHC) have long acted as a main system to study parasite-driven selection. Yet, MHC code for proteins involved in relatively slow, advanced, and evolutionary younger innate immune response. In the current project, I study the evolution of innate immunity genes (toll-like receptors) and selected cytokines (TNF, IFN) in the context of susceptibility to parasitic infections.
Polymorphism of immunity genes in wolf Canis lupus.
INTER, Foundation for Polish Science
The project by Robert Mysłajek who has been studying wolves in Poland since 1990s. In the project, we genotyped over 100 individuals in three MHC loci, and currently we work on TLRs.
The impact of MHC genes on parasite burden and winter survival of root vole Microtus oeconomus.
2009-2011, Polish Ministry of Science, Grant no. N304 168836
The aim of the project was to verify the fitness consequences of “beneficial” MHC alleles under natural conditions. In Biebrza Marshes, we studied the parasite-dependent winter survival of root voles. We found that helminth burden did not affect survival but infection with blood parasite Babesia did, and voles that had allele associated with lower Babesia burden survived better than others.